They include several diseases of mitochondria, the organs of the cells responsible for energy production. By this term we refer to the following muscle abnormalities:
Many genes are involved in either mitochondrial or nuclear genetic material and mutations may result in this condition, which are either inherited either by the mother or by both parents respectively, or they may be sporadic.
Some of the symptoms that may occur are:
Nervous system damage, ocular (eg cataracts) and acoustic problems, cardiac dysfunction, skeletal muscle abnormalities and muscle weakness, gastrointestinal disorders, muscle pain, fatigue and lack of endurance, inability to balance, difficulty in swallowing, learning difficulties, ataxia and seizures .
There is no cure, but the treatment of individual symptoms. Indicatively, the following interventions are included: use of hearing aids and spectacles, appropriate medication (eg. for treating crises and pain), the use of ancillary means of movement (eg use of a club, a wheelchair), occupational and speech therapy, temporary or permanent respiratory support, dietary supplements (eg creatine, L-carnitine, coenzyme Q10).
To monitor clinical trials on the diseases, visit: https://clinicaltrials.gov/ct2/home
Muscular Dystrophy Association